SCHEMBL6873643

SCHEMBL6873643

C=NOCCc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45
IDO1 P14902 1/20 0.45
TAAR1 Q96RJ0 2/20 0.45
ALDH1A1 P00352 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
ALOX12 P18054 1/20 0.44
CASP1 P29466 1/20 0.44
HSD17B10 Q99714 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
TDP1 Q9NUW8 3/20 0.42
CYP2A6 P11509 1/20 0.42
HTR2A P28223 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
HCAR2 Q8TDS4 1/20 0.40
MAOA P21397 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27576298 0.80 MAOA (0.45) IDO1TAAR1ALDH1A1HPGDALOX15
SCHEMBL6873640 0.79 CA1 (0.44) CA1CA2CA9IDO1TAAR1
SCHEMBL3819917 0.79 CA1 (0.48) CA1CA2CA9IDO1TAAR1
SCHEMBL214681 0.78 TSHR (0.52) CA1CA2CA9IDO1ALDH1A1
SCHEMBL4883430 0.77 TAAR1 (0.54) CA1CA2CA9IDO1TAAR1
Hydrochloric Acid SCHEMBL3952996 0.77 CA1 (0.47) CA1CA2CA9IDO1TAAR1
SCHEMBL58390 0.75 CA1 (0.48) CA1CA2CA9IDO1TAAR1
SCHEMBL14667499 0.74 TAAR1 (0.51) CA1CA2CA9IDO1TAAR1
SCHEMBL10773629 0.74 HTR3A (0.50) CA1CA2CA9IDO1TAAR1
SCHEMBL14667502 0.74 MAPT (0.46) CA1CA2CA9IDO1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107148409-B Substituted bicyclic compounds 百时美施贵宝公司 2020-07-10 CN disclosed
CN-102307903-A Novel semi-synthetic glycopeptides as antibacterial agents LEAD THERAPEUTICS INC 2012-01-04 CN disclosed
CN-101959849-A Novel semi-synthetic glycopeptides as antibacterial agents LEAD THERAPEUTICS INC 2011-01-26 CN disclosed
CN-100400487-C Glucocorticoid receptor modulators PFIZER PROD INC (US) 2008-07-09 CN disclosed
CN-1275917-C Glucocorticoid receptor modulators PFIZER PROD INC (US) 2006-09-20 CN disclosed
CN-1781890-A Glucocorticoid receptor modulators PFIZER PROD INC (US) 2006-06-07 CN disclosed
EP-1149094-B1 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS BASILEA PHARMACEUTICA AG (CH) 2004-04-21 EP disclosed
CN-1349485-A Glucocorticoid receptor modulators PFIZER PROD INC (US) 2002-05-15 CN disclosed
US-6376491-B1 BENZOFURAN DERIVATIVES FOR TREATMENT OR PREVENTION OF MYCOSIS IN MAMMALS BASILEA PHARMACEUTICA AG (CH) 2002-04-23 US disclosed
EP-1149094-A2 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS Basilea Pharmaceutica AG (CH) 2001-10-31 EP disclosed
WO-2000037464-A2 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS BASILEA PHARMACEUTICA AG (CH) 2000-06-29 WO disclosed
CN-1229412-A Interleukin-1 beta converting enzyme inhibitors VERTEX PHARMA (US) 1999-09-22 CN disclosed
EP-0838471-A1 PEPTIDE DERIVATIVES AND ANGIOTENSIN IV RECEPTOR AGONIST SAGAMI CHEMICAL RESEARCH CENTER (JP) 1998-04-29 EP disclosed