Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876315 | 1.00 | ADRA2A (0.42) | ADRA2AMCHR1APPBCHEACHE | |
| SCHEMBL6867923 | 0.89 | MCHR1 (0.45) | ADRA2AMCHR1APPBCHEACHE | |
| SCHEMBL6867919 | 0.89 | MCHR1 (0.45) | ADRA2AMCHR1APPBCHEACHE | |
| SCHEMBL6877262 | 0.87 | ADRA2A (0.48) | ADRA2AMCHR1APPBCHEACHE | |
| SCHEMBL6460350 | 0.87 | ADRA2A (0.48) | ADRA2AMCHR1APPBCHEACHE | |
| SCHEMBL6874187 | 0.86 | ADRA2A (0.45) | ADRA2AMCHR1KDM4EMEN1GAA | |
| SCHEMBL6875761 | 0.86 | MCHR1 (0.41) | ADRA2AMCHR1APPBCHEACHE | |
| SCHEMBL6874201 | 0.86 | ADRA2A (0.45) | ADRA2AMCHR1KDM4EMEN1GAA | |
| SCHEMBL6459434 | 0.86 | MCHR1 (0.41) | ADRA2AMCHR1APPBCHEACHE | |
| SCHEMBL6875692 | 0.85 | ALDH1A1 (0.52) | ADRA2AMCHR1APPBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |