Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.48 |
| ▸ | F12 | P00748 | 6/20 | 0.38 |
| ▸ | F2 | P00734 | 4/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869475 | 0.86 | ADORA2A (0.55) | ADORA2AF12F2CRHR1HCRTR1 | |
| SCHEMBL6874003 | 0.81 | ADORA2A (0.59) | ADORA2A | |
| SCHEMBL6867998 | 0.81 | ADORA2A (0.52) | ADORA2AF12F2PLAUKLKB1 | |
| SCHEMBL6867654 | 0.80 | ADORA2A (0.51) | ADORA2AF12F2PLAU | |
| SCHEMBL6871499 | 0.80 | ADORA2A (0.47) | ADORA2AF12F2PLAUKLKB1 | |
| SCHEMBL6867223 | 0.78 | ADORA2A (0.60) | ADORA2AF12F2PLAUKLKB1 | |
| SCHEMBL6872444 | 0.75 | ADORA2A (0.48) | ADORA2AF12F2PLAUKLKB1 | |
| SCHEMBL6869823 | 0.75 | ADORA2A (0.56) | ADORA2AF12F2PLAUHTR1A | |
| SCHEMBL6871898 | 0.74 | ADORA2A (0.62) | ADORA2AF12F2PLAUKLKB1 | |
| SCHEMBL6873153 | 0.73 | ADORA2A (0.38) | ADORA2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | claimed |