Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467595 | 1.00 | LMNA (0.53) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6876052 | 0.89 | NPY5R (0.46) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6457143 | 0.89 | NPY5R (0.46) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6458392 | 0.88 | APP (0.49) | HTTADRA2AMCHR1ACHEBCHE | |
| SCHEMBL6874250 | 0.88 | ADRA2A (0.46) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6457965 | 0.88 | ADRA2A (0.46) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6458400 | 0.88 | APP (0.49) | HTTADRA2AMCHR1ACHEBCHE | |
| SCHEMBL6874191 | 0.86 | BCHE (0.44) | LMNAHTTHTR1AACHEBCHE | |
| SCHEMBL6458578 | 0.86 | BCHE (0.44) | LMNAHTTHTR1AACHEBCHE | |
| SCHEMBL13797392 | 0.85 | MCHR1 (0.58) | LMNAHTTKMT2AOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |