Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 5/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR1B | P28222 | 3/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6458578 | 1.00 | BCHE (0.44) | BCHEACHEHTR1AHTR1BHTR4 | |
| SCHEMBL6878474 | 0.90 | BCHE (0.43) | BCHEACHEHTR1AHTR1BHTR4 | |
| SCHEMBL6456848 | 0.90 | BCHE (0.43) | BCHEACHEHTR1AHTR1BHTR4 | |
| SCHEMBL6457965 | 0.88 | ADRA2A (0.46) | BCHEACHEHTR1AHTR2AMTNR1A | |
| SCHEMBL6874250 | 0.88 | ADRA2A (0.46) | BCHEACHEHTR1AHTR2AMTNR1A | |
| SCHEMBL6467595 | 0.86 | LMNA (0.53) | BCHEACHEHTR1ALMNAALDH1A1 | |
| SCHEMBL6875174 | 0.86 | LMNA (0.53) | BCHEACHEHTR1ALMNAALDH1A1 | |
| SCHEMBL6459434 | 0.84 | MCHR1 (0.41) | BCHEACHEL3MBTL1LMNAKDM4E | |
| SCHEMBL6875761 | 0.84 | MCHR1 (0.41) | BCHEACHEL3MBTL1LMNAKDM4E | |
| SCHEMBL6874201 | 0.84 | ADRA2A (0.45) | CYP1A2CYP2D6L3MBTL1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |