Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.64 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.64 |
| ▸ | THPO | P40225 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9474712 | 0.89 | LMNA (0.53) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL27414896 | 0.89 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL27300689 | 0.88 | MAPT (0.50) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL2446964 | 0.87 | ANPEP (0.50) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL687298 | 0.87 | ANPEP (0.50) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL30789009 | 0.87 | ANPEP (0.50) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL3718382 | 0.85 | MAPT (0.66) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL688834 | 0.83 | ALDH1A1 (0.42) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL1891064 | 0.82 | ALDH1A1 (0.41) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 | |
| SCHEMBL26396596 | 0.82 | PARP1 (0.49) | MAPTSMN1; SMN2LMNAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102911057-B | A kind of preparation method of ketoprofen | JIUZHOU PHARMACEUTICAL CO., LTD., ZHEJIANG (CN) | 2016-01-27 | — | — | CN | claimed |
| CN-102911057-A | Preparation method of ketoprofen ethyl ester | ZHEJIANG JIUZHOU PHARM CO LTD | 2013-02-06 | — | — | CN | claimed |
| EP-0344737-B1 | PROCESS FOR PURIFYING ALPHA-SUBSTITUTED ACETIC ACIDS | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-18 | — | — | EP | claimed |
| US-5089405-A | Hydrolysis of racemic 2-arylpropionamides | RHONE-POULENC SANTE (FR) | 1992-02-18 | — | — | US | claimed |
| US-4970336-A | Method of purifying α-substituted acetic acids | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1990-11-13 | — | — | US | claimed |
| EP-0344737-A1 | Process for purifying alpha-substituted acetic acids | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-12-06 | — | — | EP | claimed |
| CN-115684400-B | HPLC detection method for ketoprofen ethyl ester in water and algae culture medium | 贵州健安德科技有限公司 | 2025-06-24 | — | — | CN | disclosed |
| CN-116444398-B | Preparation method of ketoprofen intermediate formula III | 浙江瑞博制药有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-117417245-A | Method for synthesizing ketoprofen through pyrolytic aromatization reaction | 复旦大学 | 2024-01-19 | — | — | CN | disclosed |
| CN-116554017-A | Three-step preparation method of ketoprofen general formula compound | 浙江瑞博制药有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-116444398-A | Preparation method of ketoprofen intermediate formula III | 浙江瑞博制药有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-116444361-A | Six-step preparation method of ketoprofen general formula compound | 浙江瑞博制药有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-109651155-B | Ketone ibuprofen intermediate and preparation method and application thereof | 浙江瑞博制药有限公司 | 2023-04-11 | — | — | CN | disclosed |
| US-4761508-A | 1,1-(3-ethylphenyl)phenylethylene and method for preparing it | NIPPON PETROCHEMICALS CO., LTD. (JP) | 1988-08-02 | — | — | US | disclosed |
| EP-0209905-A1 | 1,1-(3-Ethylphenyl)phenylethylene and method for its preparation | NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) | 1987-01-28 | — | — | EP | disclosed |
| EP-0025262-B1 | ALPHA-THIO-ALPHA-ARYL-SUBSTITUTED ALKANONITRILES, PROCESS FOR THEIR PREPARATION, PROCESS FOR PREPARING ALPHA-ARYL-SUBSTITUTED ALKANONITRILES AND THE CORRESPONDING CARBOXYLIC ACIDS THEREFROM AND PROCESS FOR PREPARING INTERMEDIATES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1983-10-05 | — | — | EP | disclosed |
| US-4340740-A | Alpha-thio-alpha-aryl-substituted alkanonitrile and process for preparing alpha-aryl-substituted alkanonitrile therefrom | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1982-07-20 | — | — | US | disclosed |
| EP-0025262-A2 | Alpha-thio-alpha-aryl-substituted alkanonitriles, process for their preparation, process for preparing alpha-aryl-substituted alkanonitriles and the corresponding carboxylic acids therefrom and process for preparing intermediates | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1981-03-18 | — | — | EP | disclosed |
| US-4230884-A | METHYLATION, HYDROLYSIS, WITH CATALYST | LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) | 1980-10-28 | — | — | US | disclosed |
| US-4201870-A | Process for the preparation of 2-(3-benzoylphenyl)-propionic acid | LEK TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) | 1980-05-06 | — | — | US | disclosed |