Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.66 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687542 | 0.85 | MAPT (0.64) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11835373 | 0.84 | ALDH1A1 (0.52) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL764365 | 0.82 | MAPT (0.74) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| Dexketoprofen SCHEMBL6357571 | 0.81 | PTGS1 (0.97) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| Ketoprofen SCHEMBL1248409 | 0.81 | PTGS1 (0.97) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4669024 | 0.81 | PTGS1 (0.72) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19788333 | 0.81 | PTGS1 (0.72) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL31150150 | 0.81 | PTGS1 (0.72) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL13653040 | 0.81 | PTGS1 (0.72) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL13220676 | 0.79 | MAPT (0.70) | MAPTPTGS1PTGS2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181084-A | Optimization of synthesis process and pharmacological activity research of daphnetin derivatives | 中国药科大学 | 2022-10-14 | — | — | CN | claimed |
| EP-0328111-B1 | Cancer cell metastasis inhibitors | MEIJI SEIKA CO (JP) | 2000-01-19 | — | — | EP | claimed |
| US-4711879-A | IMMUNO-MODULATING ACTIVITY | CIBA-GEIGY CORPORATION (US) | 1987-12-08 | — | — | US | claimed |
| US-4640911-A | IMMUNOSTIMULANTS, VIRICIDES SUCH AS HERPES SIMPLEX | CIBA-GEIGY CORPORATION (US) | 1987-02-03 | — | — | US | claimed |
| EP-0163286-A2 | Acylated sugars, method for their preparation and their use | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | claimed |
| EP-0024282-B1 | BENZOYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1983-05-18 | — | — | EP | claimed |
| EP-0024282-A1 | Benzoyl derivatives, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | claimed |
| CN-115181084-A | Optimization of synthesis process and pharmacological activity research of daphnetin derivatives | 中国药科大学 | 2022-10-14 | — | — | CN | disclosed |
| EP-3273956-B1 | NITROXIDE RADICALS FOR THE TREATMENT OF DISEASES OF THE RESPIRATORY TRACT | YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIV OF JERUSALEM LTD (IL) | 2020-05-06 | — | — | EP | disclosed |
| US-10441568-B2 | Nitroxide radicals for the treatment of diseases of the respiratory tract | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2019-10-15 | — | — | US | disclosed |
| US-20180085347-A1 | NITROXIDE RADICALS FOR THE TREATMENT OF DISEASES OF THE RESPIRATORY TRACT | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2018-03-29 | — | — | US | disclosed |
| EP-3273956-A1 | NITROXIDE RADICALS FOR THE TREATMENT OF DISEASES OF THE RESPIRATORY TRACT | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016151591-A1 | NITROXIDE RADICALS FOR THE TREATMENT OF DISEASES OF THE RESPIRATORY TRACT | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2016-09-29 | — | — | WO | disclosed |
| EP-0024282-A1 | Benzoyl derivatives, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |
| US-4217352-A | ANTIARTHRITIC AGENT | MERCK & CO., INC. (US) | 1980-08-12 | — | — | US | disclosed |
| US-4212976-A | ANTIARTHRITIC AGENTS | MERCK & CO., INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4144342-A | ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. (US) | 1979-03-13 | — | — | US | disclosed |
| US-4061759-A | ANTIINFLAMMATORY, ARTHRITIS | MERCK & CO., INC. (US) | 1977-12-06 | — | — | US | disclosed |
| US-4057637-A | RHEUMATOID ARTHRITIS | MERCK & CO., INC. (US) | 1977-11-08 | — | — | US | disclosed |
| US-3971797-A | ANTIARTHRITIC | MERCK & CO., INC. (US) | 1976-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10441568-B2 | Nitroxide radicals for the treatment of diseases of the respiratory tract | TXNRD2, ARG2, TXN2 | MAPT 4738/4885PTGS1 131/4885PTGS2 142/4885 |
| US-20180085347-A1 | NITROXIDE RADICALS FOR THE TREATMENT OF DISEASES OF THE RESPIRATORY TRACT | TXNRD2, ARG2, TXN2 | MAPT 4738/4885PTGS1 131/4885PTGS2 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.