Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 6/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875477 | 1.00 | KCNH2 (0.43) | KCNH2CYP2D6GRIN2BMCHR1ADRA2A | |
| SCHEMBL6875677 | 0.91 | MCHR1 (0.41) | KCNH2CYP2D6MCHR1ADRA2ANPY5R | |
| SCHEMBL6875669 | 0.91 | MCHR1 (0.41) | KCNH2CYP2D6MCHR1ADRA2ANPY5R | |
| SCHEMBL6876140 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RMAPK8HTR2B | |
| SCHEMBL6876132 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RMAPK8HTR2B | |
| SCHEMBL6880166 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RACHEDRD2 | |
| SCHEMBL6464914 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RACHEDRD2 | |
| SCHEMBL6873584 | 0.90 | MCHR1 (0.42) | KCNH2CYP2D6GRIN2BMCHR1ADRA2A | |
| SCHEMBL6873577 | 0.90 | MCHR1 (0.42) | KCNH2CYP2D6GRIN2BMCHR1ADRA2A | |
| SCHEMBL6880445 | 0.89 | MCHR1 (0.43) | KCNH2CYP2D6GRIN2BMCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |