Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876132 | 1.00 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RACHEADRA1A | |
| SCHEMBL6875897 | 0.94 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RACHEADRA1A | |
| SCHEMBL6875902 | 0.94 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RACHEADRA1A | |
| SCHEMBL6875677 | 0.90 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6875477 | 0.90 | KCNH2 (0.43) | MCHR1ADRA2ANPY5RACHEADRA1A | |
| SCHEMBL6875484 | 0.90 | KCNH2 (0.43) | MCHR1ADRA2ANPY5RACHEADRA1A | |
| SCHEMBL6875669 | 0.90 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6880166 | 0.89 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6464914 | 0.89 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6873584 | 0.89 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RACHEADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |