Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875739 | 1.00 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BSIGMAR1 | |
| SCHEMBL6879853 | 0.89 | LMNA (0.57) | MCHR1ADRA2AHRH1HTR2BSIGMAR1 | |
| SCHEMBL6879858 | 0.89 | LMNA (0.57) | MCHR1ADRA2AHRH1HTR2BSIGMAR1 | |
| SCHEMBL6458834 | 0.86 | MCHR1 (0.57) | MCHR1ADRA2AHRH1HTR2BSIGMAR1 | |
| SCHEMBL6458825 | 0.86 | MCHR1 (0.57) | MCHR1ADRA2AHRH1HTR2BSIGMAR1 | |
| SCHEMBL6465720 | 0.85 | MCHR1 (0.51) | MCHR1ADRA2AHRH1HTR2BAURKB | |
| SCHEMBL6465711 | 0.85 | MCHR1 (0.51) | MCHR1ADRA2AHRH1HTR2BAURKB | |
| Hydrochloric Acid SCHEMBL6459084 | 0.85 | MCHR1 (0.56) | MCHR1ADRA2AHRH1HTR2BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL6459091 | 0.85 | MCHR1 (0.56) | MCHR1ADRA2AHRH1HTR2BSIGMAR1 | |
| SCHEMBL6880089 | 0.85 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |