Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | HTR2B | P41595 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880084 | 1.00 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BKMT2A | |
| SCHEMBL6467548 | 0.89 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BKMT2A | |
| SCHEMBL6467545 | 0.89 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BKMT2A | |
| Hydrochloric Acid SCHEMBL6456668 | 0.89 | MCHR1 (0.46) | MCHR1ADRA2AHRH1HTR2BKMT2A | |
| Hydrochloric Acid SCHEMBL6456673 | 0.89 | MCHR1 (0.46) | MCHR1ADRA2AHRH1HTR2BKMT2A | |
| SCHEMBL6875733 | 0.85 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875739 | 0.85 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879858 | 0.83 | LMNA (0.57) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879853 | 0.83 | LMNA (0.57) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873326 | 0.81 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |