Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16447278 | 0.95 | HPGD (0.65) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A | |
| SCHEMBL16055314 | 0.90 | MRGPRX4 (0.53) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A | |
| SCHEMBL6865198 | 0.87 | HPGD (0.71) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A | |
| SCHEMBL16055179 | 0.86 | HPGD (0.62) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A | |
| SCHEMBL6865895 | 0.86 | CREBBP (0.49) | LMNAKDM4EPOLBMEN1KMT2A | |
| SCHEMBL18660058 | 0.85 | SMN1; SMN2 (0.62) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A | |
| SCHEMBL30820546 | 0.85 | SMN1; SMN2 (0.62) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A | |
| SCHEMBL2338199 | 0.82 | HPGD (0.76) | LMNAHPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL16015342 | 0.82 | LMNA (0.67) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A | |
| SCHEMBL28448203 | 0.82 | HPGD (0.71) | LMNAHPGDMRGPRX4SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821980-B1 | Substituted 5-benzyl-2,4-diaminopyrimidines | BASILEA PHARMACEUTICA AG (CH) | 2004-11-23 | — | — | US | disclosed |