Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | BACE1 | P56817 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875945 | 1.00 | ACHE (0.41) | ACHEBACE1BCHEADRA2AMCHR1 | |
| SCHEMBL6829020 | 0.88 | MCHR1 (0.40) | ACHEBACE1ADRA2AMCHR1SMN1; SMN2 | |
| SCHEMBL6878044 | 0.88 | MCHR1 (0.40) | ACHEBACE1ADRA2AMCHR1SMN1; SMN2 | |
| SCHEMBL6869175 | 0.86 | KDM1A (0.44) | ACHEBACE1BCHEADRA2AMCHR1 | |
| SCHEMBL6869183 | 0.86 | KDM1A (0.44) | ACHEBACE1BCHEADRA2AMCHR1 | |
| SCHEMBL6876275 | 0.85 | ACHE (0.54) | ACHEBACE1BCHEPOLBMEN1 | |
| SCHEMBL6876285 | 0.85 | ACHE (0.54) | ACHEBACE1BCHEPOLBMEN1 | |
| SCHEMBL6878316 | 0.84 | TSHR (0.46) | ACHEBACE1ADRA2AMCHR1MEN1 | |
| SCHEMBL6878307 | 0.84 | TSHR (0.46) | ACHEBACE1ADRA2AMCHR1MEN1 | |
| SCHEMBL6877433 | 0.84 | ACHE (0.42) | ACHEBACE1BCHEADRA2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |