Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.46 |
| ▸ | USP2 | O75604 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878316 | 1.00 | TSHR (0.46) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6877439 | 0.89 | ACHE (0.42) | ALDH1A1KMT2AMEN1MCHR1ACHE | |
| SCHEMBL6877433 | 0.89 | ACHE (0.42) | ALDH1A1KMT2AMEN1MCHR1ACHE | |
| SCHEMBL6874596 | 0.88 | APLNR (0.44) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6459873 | 0.88 | APLNR (0.44) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6875945 | 0.84 | ACHE (0.41) | TSHRHSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL6875957 | 0.84 | ACHE (0.41) | TSHRHSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL6873081 | 0.84 | TSHR (0.51) | TSHRALDH1A1FLT3TYRO3MERTK | |
| SCHEMBL6873078 | 0.84 | TSHR (0.51) | TSHRALDH1A1FLT3TYRO3MERTK | |
| SCHEMBL6875163 | 0.84 | EIF2AK2 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C19USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |