Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869175 | 1.00 | KDM1A (0.44) | KDM1AMAOAADRA2AMCHR1ACHE | |
| SCHEMBL6455824 | 0.89 | MCHR1 (0.46) | KDM1AMAOAADRA2AMCHR1ACHE | |
| SCHEMBL6876612 | 0.89 | MCHR1 (0.46) | KDM1AMAOAADRA2AMCHR1ACHE | |
| SCHEMBL6875610 | 0.86 | KDM1A (0.46) | KDM1AMAOAADRA2AMCHR1ACHE | |
| SCHEMBL6875616 | 0.86 | KDM1A (0.46) | KDM1AMAOAADRA2AMCHR1ACHE | |
| SCHEMBL6877433 | 0.86 | ACHE (0.42) | ADRA2AMCHR1ACHEAPPBCHE | |
| SCHEMBL6877439 | 0.86 | ACHE (0.42) | ADRA2AMCHR1ACHEAPPBCHE | |
| SCHEMBL6875945 | 0.86 | ACHE (0.41) | ADRA2AMCHR1ACHEBCHEMAPK8 | |
| SCHEMBL6875957 | 0.86 | ACHE (0.41) | ADRA2AMCHR1ACHEBCHEMAPK8 | |
| SCHEMBL6867978 | 0.85 | ADRA2A (0.42) | ADRA2AMCHR1ACHEMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |