Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | GLI1 | P08151 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 4/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14761896 | 0.84 | NOS2 (0.38) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL1358236 | 0.83 | NOS2 (0.43) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL7096783 | 0.82 | PRCP (0.40) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL28130344 | 0.81 | NOS2 (0.44) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL10030565 | 0.81 | NOS2 (0.42) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL2010421 | 0.81 | NOS2 (0.42) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL26117510 | 0.79 | NOS2 (0.41) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL10519805 | 0.79 | PRCP (0.41) | NOS2NOS3NOS1DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL10519803 | 0.78 | PRCP (0.40) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL8815499 | 0.78 | DPP4 (0.38) | NOS2NOS3NOS1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458680-A1 | PRODRUGS TO D-PROLINES | F. Hoffmann-La Roche AG (CH) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051836-A1 | PRODRUGS TO D-PROLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |