Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.41 |
| ▸ | BCHE | P06276 | 7/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876358 | 1.00 | ACHE (0.41) | ACHEBCHEADRA1DADRA1AADRA1B | |
| SCHEMBL6868494 | 0.90 | ACHE (0.40) | ACHEBCHEADRA2AMCHR1 | |
| SCHEMBL6877600 | 0.90 | ACHE (0.40) | ACHEBCHEADRA2AMCHR1 | |
| SCHEMBL6877596 | 0.90 | ACHE (0.40) | ACHEBCHEADRA2AMCHR1 | |
| SCHEMBL6868489 | 0.90 | ACHE (0.40) | ACHEBCHEADRA2AMCHR1 | |
| SCHEMBL6877746 | 0.88 | ALDH1A1 (0.45) | ADRA1AABCB1TUBB3ADRA2AMCHR1 | |
| SCHEMBL6877742 | 0.88 | ALDH1A1 (0.45) | ADRA1AABCB1TUBB3ADRA2AMCHR1 | |
| SCHEMBL6872959 | 0.85 | MCHR1 (0.40) | ACHEBCHEADRA1AADRA2AMCHR1 | |
| SCHEMBL6872955 | 0.85 | MCHR1 (0.40) | ACHEBCHEADRA1AADRA2AMCHR1 | |
| SCHEMBL13796718 | 0.83 | MCHR1 (0.57) | ACHEBCHEADRA1AADRA2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |