Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876357 | 1.00 | MCHR1 (0.47) | MCHR1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL6880147 | 0.89 | MCHR1 (0.49) | MCHR1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL27652810 | 0.89 | MCHR1 (0.49) | MCHR1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL6878610 | 0.88 | MCHR1 (0.48) | MCHR1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL6878604 | 0.88 | MCHR1 (0.48) | MCHR1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL6879386 | 0.88 | MCHR1 (0.47) | MCHR1SMN1; SMN2KDM4ELMNANPC1 | |
| SCHEMBL6879382 | 0.88 | MCHR1 (0.47) | MCHR1SMN1; SMN2KDM4ELMNANPC1 | |
| SCHEMBL6878294 | 0.86 | KDM4E (0.48) | MCHR1KDM4ENPY5RADRA2ACNR1 | |
| SCHEMBL6878289 | 0.86 | KDM4E (0.48) | MCHR1KDM4ENPY5RADRA2ACNR1 | |
| SCHEMBL6876641 | 0.85 | MCHR1 (0.43) | MCHR1SMN1; SMN2KDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |