Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 11/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687744 | 0.95 | PTGER3 (0.43) | PTGER3RXFP1NPSR1CNR2SLC22A12 | |
| SCHEMBL687242 | 0.89 | SMN1; SMN2 (0.44) | PTGER3NPSR1CNR2SLC22A12ITGB1 | |
| SCHEMBL688053 | 0.89 | PTGER3 (0.43) | PTGER3RXFP1CNR2SLC22A12TP53 | |
| SCHEMBL686799 | 0.88 | PTGER3 (0.51) | PTGER3CNR2SLC22A12MAPT | |
| SCHEMBL687712 | 0.88 | PTGER3 (0.43) | PTGER3CNR2SLC22A12SLC16A3SLC16A1 | |
| SCHEMBL687324 | 0.87 | PTGER3 (0.41) | PTGER3RXFP1NPSR1SLC16A3SLC16A1 | |
| SCHEMBL687980 | 0.87 | ITGB1 (0.41) | PTGER3CNR2SLC22A12ITGB1ITGA4 | |
| SCHEMBL687624 | 0.87 | PTGER3 (0.42) | PTGER3RXFP1CNR2SLC22A12TP53 | |
| SCHEMBL686842 | 0.86 | PTGER3 (0.45) | PTGER3RXFP1NPSR1CNR2SLC22A12 | |
| SCHEMBL686846 | 0.86 | PTGER3 (0.41) | PTGER3CNR2SLC22A12ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |