Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687242 | 0.93 | SMN1; SMN2 (0.44) | ITGB1ITGA4SMN1; SMN2PTGER3CNR2 | |
| SCHEMBL687744 | 0.88 | PTGER3 (0.43) | PTGER3CNR2LMNASLC22A12CTSA | |
| SCHEMBL688233 | 0.87 | PTGER3 (0.43) | SMN1; SMN2PTGER3CNR2CYP26A1SLC22A12 | |
| SCHEMBL687640 | 0.87 | PTGER3 (0.40) | ITGB1ITGA4PTGER3CNR2LMNA | |
| SCHEMBL687923 | 0.86 | PTGER3 (0.41) | ITGB1ITGA4PTGER3CNR2SLC22A12 | |
| SCHEMBL688669 | 0.86 | PTGER3 (0.42) | ITGB1ITGA4PTGER3CNR2CTSA | |
| SCHEMBL688215 | 0.86 | PTGER3 (0.43) | ITGB1ITGA4PTGER3CTSA | |
| SCHEMBL688170 | 0.86 | PTGER3 (0.41) | ITGB1ITGA4SMN1; SMN2PTGER3CNR2 | |
| SCHEMBL687765 | 0.86 | KMT2A (0.37) | ITGB1ITGA4SMN1; SMN2PTGER3KMT2A | |
| SCHEMBL688343 | 0.85 | PTGER3 (0.43) | SMN1; SMN2PTGER3CNR2SLC22A12CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |