Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.53 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227969 | 0.88 | HRH4 (0.45) | HRH4CYP51A1SMYD3DRD2RBP4 | |
| SCHEMBL6873804 | 0.88 | HRH4 (0.43) | HRH4CYP51A1SMYD3DRD2AKR1C3 | |
| SCHEMBL2227562 | 0.84 | DRD2 (0.42) | HRH4CYP51A1SMYD3DRD2AKR1C3 | |
| SCHEMBL1550512 | 0.83 | DRD2 (0.42) | HRH4CYP51A1SMYD3DRD2PDE10A | |
| SCHEMBL1550154 | 0.77 | HRH4 (0.38) | HRH4SMYD3DRD2SMN1; SMN2PDE10A | |
| SCHEMBL1550169 | 0.77 | ALOX15 (0.44) | HRH4CYP51A1SMYD3HRH3PDE10A | |
| SCHEMBL1550577 | 0.77 | TP53 (0.39) | HRH4SMYD3DRD2AKR1C3POLB | |
| SCHEMBL1550827 | 0.77 | PYGL (0.44) | CYP51A1SMYD3 | |
| SCHEMBL1550291 | 0.76 | CYP51A1 (0.42) | HRH4CYP51A1SMYD3HRH3PDE10A | |
| SCHEMBL1549798 | 0.76 | AR (0.42) | HRH4CYP51A1SMYD3DRD2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |