Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.46 |
| ▸ | ITGAV | P06756 | 3/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | CTSA | P10619 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27553827 | 0.89 | ITGB3 (0.44) | ITGB3ITGAV | |
| SCHEMBL27553828 | 0.89 | ITGB3 (0.44) | ITGB3ITGAV | |
| SCHEMBL9304020 | 0.83 | KMT2A (0.57) | MEN1KMT2AMAPTSAE1UBA2 | |
| SCHEMBL9304024 | 0.83 | KMT2A (0.57) | MEN1KMT2AMAPTSAE1UBA2 | |
| SCHEMBL9304030 | 0.83 | KMT2A (0.57) | MEN1KMT2AMAPTSAE1UBA2 | |
| SCHEMBL5408556 | 0.80 | UTS2R (0.57) | CYP26A1CTSASMN1; SMN2 | |
| SCHEMBL687855 | 0.76 | TAS1R3 (0.43) | MAPTCYP26A1KEAP1NFE2L2CTSA | |
| SCHEMBL13410007 | 0.76 | MEN1 (0.44) | MEN1KMT2AMAPTSAE1UBA2 | |
| SCHEMBL20545977 | 0.72 | CYP26A1 (0.38) | MEN1KMT2AMAPTSAE1UBA2 | |
| SCHEMBL20545975 | 0.72 | CYP26A1 (0.38) | MEN1KMT2AMAPTSAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |