Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.53 |
| ▸ | FYN | P06241 | 11/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146861 | 0.86 | PDE4D (0.70) | PDE4DFYN | |
| SCHEMBL509949 | 0.84 | PDE4D (0.77) | PDE4DFYN | |
| SCHEMBL14888542 | 0.81 | NUDT1 (0.58) | FYNKDM4E | |
| SCHEMBL7043841 | 0.79 | MAPT (0.51) | PDE4DFYNKDM4E | |
| SCHEMBL7145674 | 0.79 | PDE10A (0.50) | PDE4DPOLB | |
| SCHEMBL7766283 | 0.79 | FYN (0.47) | PDE4DFYNKDM4EPOLBNPSR1 | |
| SCHEMBL7146570 | 0.78 | PDE4D (0.48) | PDE4DFYN | |
| SCHEMBL6876513 | 0.78 | PDE4D (0.48) | PDE4DFYN | |
| SCHEMBL2250839 | 0.78 | PDE4D (0.64) | PDE4DKDM4E | |
| SCHEMBL7150018 | 0.76 | DYRK3 (0.47) | PDE4DFYNKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |