Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877019 | 1.00 | MAPK8 (0.39) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6867607 | 0.86 | MAPK8 (0.39) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6867614 | 0.86 | MAPK8 (0.39) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6878052 | 0.80 | HRH4 (0.42) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6878045 | 0.80 | HRH4 (0.42) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6877758 | 0.79 | LCK (0.39) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6877753 | 0.79 | LCK (0.39) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6868816 | 0.79 | CNR1 (0.39) | MAPK8MAPK9MAPK10MAPK14JAK3 | |
| SCHEMBL6876317 | 0.78 | MCHR1 (0.38) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6876313 | 0.78 | MCHR1 (0.38) | MCHR1ADRA2AADRA1AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |