Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.38 |
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877758 | 1.00 | LCK (0.39) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6878052 | 0.91 | HRH4 (0.42) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6878045 | 0.91 | HRH4 (0.42) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6879291 | 0.84 | MAPK14 (0.40) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6879294 | 0.84 | MAPK14 (0.40) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6868816 | 0.82 | CNR1 (0.39) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6877016 | 0.79 | MAPK8 (0.39) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6877019 | 0.79 | MAPK8 (0.39) | LCKJAK3MCHR1ADRA2AHRH1 | |
| SCHEMBL6877440 | 0.78 | MAPK8 (0.40) | JAK3MCHR1MAPK8MAPK9MAPK10 | |
| SCHEMBL6877450 | 0.78 | MAPK8 (0.40) | JAK3MCHR1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |