Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877124 | 1.00 | EPHX2 (0.47) | EPHX2DRD2EPHX1MAPK8MAPK9 | |
| SCHEMBL6874037 | 0.90 | AURKA (0.50) | EPHX2DRD2MAPK8MAPK9MAPK10 | |
| SCHEMBL6874044 | 0.90 | AURKA (0.50) | EPHX2DRD2MAPK8MAPK9MAPK10 | |
| SCHEMBL6880107 | 0.87 | MTNR1A (0.42) | MAPK8MAPK9MAPK10MCHR1CYP2C9 | |
| SCHEMBL6880113 | 0.87 | MTNR1A (0.42) | MAPK8MAPK9MAPK10MCHR1CYP2C9 | |
| SCHEMBL6878999 | 0.85 | CNR2 (0.47) | MCHR1 | |
| SCHEMBL6876646 | 0.85 | MAPK8 (0.42) | DRD2MAPK8MAPK9MAPK10MCHR1 | |
| SCHEMBL6876639 | 0.85 | MAPK8 (0.42) | DRD2MAPK8MAPK9MAPK10MCHR1 | |
| SCHEMBL6878994 | 0.85 | CNR2 (0.47) | MCHR1 | |
| SCHEMBL6455514 | 0.83 | LMNA (0.50) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |