Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877349 | 1.00 | EPHX1 (0.56) | EPHX1KDM4ELMNASMN1; SMN2EPHX2 | |
| SCHEMBL6874008 | 0.92 | SMN1; SMN2 (0.53) | EPHX1KDM4ELMNASMN1; SMN2EPHX2 | |
| SCHEMBL6874005 | 0.92 | SMN1; SMN2 (0.53) | EPHX1KDM4ELMNASMN1; SMN2EPHX2 | |
| SCHEMBL6877589 | 0.88 | EPHX1 (0.53) | EPHX1EPHX2MAPTIGF1RKIT | |
| SCHEMBL6873823 | 0.87 | LMNA (0.53) | EPHX1KDM4ELMNASMN1; SMN2MAPT | |
| SCHEMBL6873829 | 0.87 | LMNA (0.53) | EPHX1KDM4ELMNASMN1; SMN2MAPT | |
| Trifluoroacetic Acid SCHEMBL6457766 | 0.82 | NPC1 (0.52) | KDM4ELMNASMN1; SMN2MAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL6457569 | 0.80 | KDM4E (0.52) | EPHX1KDM4ELMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6461174 | 0.80 | SMN1; SMN2 (0.49) | KDM4ELMNASMN1; SMN2EPHX2MAPT | |
| Trifluoroacetic Acid SCHEMBL6467228 | 0.79 | LMNA (0.51) | KDM4ELMNASMN1; SMN2EPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |