Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877349 | 0.88 | EPHX1 (0.56) | EPHX1EPHX2MAPTKITPDGFRA | |
| SCHEMBL6877352 | 0.88 | EPHX1 (0.56) | EPHX1EPHX2MAPTKITPDGFRA | |
| SCHEMBL6880110 | 0.87 | SIGMAR1 (0.48) | EPHX1MCHR1ADRA2AMAPTKDR | |
| SCHEMBL6880103 | 0.87 | SIGMAR1 (0.48) | EPHX1MCHR1ADRA2AMAPTKDR | |
| SCHEMBL6878665 | 0.86 | EPHX1 (0.49) | EPHX1EPHX2MCHR1ADRA2A | |
| SCHEMBL6878657 | 0.86 | EPHX1 (0.49) | EPHX1EPHX2MCHR1ADRA2A | |
| SCHEMBL6880545 | 0.85 | MAPT (0.54) | MCHR1ADRA2AMAPTKITPDGFRA | |
| SCHEMBL6880550 | 0.85 | MAPT (0.54) | MCHR1ADRA2AMAPTKITPDGFRA | |
| SCHEMBL6876945 | 0.85 | MCHR1 (0.46) | EPHX2MCHR1ADRA2A | |
| SCHEMBL6876948 | 0.85 | MCHR1 (0.46) | EPHX2MCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |