Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035558 | 0.84 | MCHR1 (0.59) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL4035559 | 0.84 | MCHR1 (0.59) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874339 | 0.84 | ADRA2A (0.44) | MCHR1ADRA2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6877335 | 0.82 | MCHR1 (0.35) | MCHR1ADRA2AALDH1A1SMN1; SMN2EHMT2 | |
| SCHEMBL6877327 | 0.82 | MCHR1 (0.35) | MCHR1ADRA2AALDH1A1SMN1; SMN2EHMT2 | |
| SCHEMBL6868204 | 0.80 | SMN1; SMN2 (0.40) | MCHR1ADRA2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6464515 | 0.80 | MCHR1 (0.50) | MCHR1ADRA2AALDH1A1HTTCNR1 | |
| SCHEMBL6463344 | 0.80 | MCHR1 (0.50) | MCHR1ADRA2AALDH1A1HTTCNR1 | |
| SCHEMBL6462144 | 0.78 | MCHR1 (0.50) | MCHR1ADRA2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6462149 | 0.78 | MCHR1 (0.50) | MCHR1ADRA2AALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |