Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 11/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877335 | 1.00 | MCHR1 (0.35) | MCHR1ADRA2AEHMT2KDM4EALDH1A1 | |
| SCHEMBL6875886 | 0.83 | MCHR1 (0.42) | MCHR1ADRA2AHTTSMN1; SMN2 | |
| SCHEMBL6875896 | 0.83 | MCHR1 (0.42) | MCHR1ADRA2AHTTSMN1; SMN2 | |
| SCHEMBL6875905 | 0.83 | MCHR1 (0.42) | MCHR1ADRA2AHTTSMN1; SMN2 | |
| SCHEMBL6877509 | 0.82 | MCHR1 (0.40) | MCHR1ADRA2AEHMT2KDM4EALDH1A1 | |
| SCHEMBL6874734 | 0.81 | LMNA (0.36) | MCHR1KDM4EALDH1A1TDP1HTT | |
| SCHEMBL6874724 | 0.81 | LMNA (0.36) | MCHR1KDM4EALDH1A1TDP1HTT | |
| SCHEMBL6866914 | 0.79 | HDAC1 (0.42) | MCHR1ADRA2A | |
| SCHEMBL6866911 | 0.79 | HDAC1 (0.42) | MCHR1ADRA2A | |
| SCHEMBL6876528 | 0.78 | MCHR1 (0.49) | MCHR1ADRA2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |