Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876882 | 0.90 | MCHR1 (0.39) | ADRA2AMCHR1EPHX1MEN1MAPT | |
| SCHEMBL7046594 | 0.88 | ALDH1A1 (0.50) | ADRA2AMCHR1EPHX1MEN1KMT2A | |
| SCHEMBL6868112 | 0.85 | MCHR1 (0.56) | ADRA2AMCHR1MAPTHTTKMT2A | |
| SCHEMBL6868116 | 0.85 | MCHR1 (0.56) | ADRA2AMCHR1MAPTHTTKMT2A | |
| SCHEMBL4030186 | 0.84 | MCHR1 (0.64) | ADRA2AMCHR1HRH1HTR2BALDH1A1 | |
| SCHEMBL4030189 | 0.84 | MCHR1 (0.64) | ADRA2AMCHR1HRH1HTR2BALDH1A1 | |
| SCHEMBL6458129 | 0.84 | ADRA2A (0.44) | ADRA2AMCHR1EPHX1MAPTHRH1 | |
| SCHEMBL6458136 | 0.84 | ADRA2A (0.44) | ADRA2AMCHR1EPHX1MAPTHRH1 | |
| SCHEMBL6877509 | 0.84 | MCHR1 (0.40) | ADRA2AMCHR1HTTSMN1; SMN2HRH1 | |
| SCHEMBL6868077 | 0.82 | MCHR1 (0.43) | ADRA2AMCHR1EPHX1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |