Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | EIF4E | P06730 | 11/20 | 0.45 |
| ▸ | PTPRF | P10586 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879620 | 0.89 | NOTUM (0.44) | EIF4EPTPRFPTPN2PTPN1RAB9A | |
| SCHEMBL6871896 | 0.88 | NOTUM (0.43) | EIF4EPTPRFPTPN2PTPN1RAB9A | |
| SCHEMBL6878789 | 0.88 | NOTUM (0.42) | ARPTPRFPTPN2PTPN1RAB9A | |
| SCHEMBL6872874 | 0.88 | NOTUM (0.42) | EIF4EMAPTNOTUMLMNACYP1A2 | |
| SCHEMBL6879641 | 0.88 | IDH1 (0.46) | EIF4ERAB9AMEN1KMT2AMAPT | |
| SCHEMBL5044794 | 0.87 | AR (0.43) | AREIF4EPTPRFPTPN2PTPN1 | |
| SCHEMBL5039301 | 0.86 | CDC25A (0.49) | EIF4ERAB9AMEN1KMT2AMAPT | |
| SCHEMBL6881405 | 0.86 | NOTUM (0.41) | EIF4EPTPRFPTPN2PTPN1RAB9A | |
| SCHEMBL6472514 | 0.85 | CNR1 (0.45) | EIF4EMEN1KMT2ANOTUMPOLB | |
| SCHEMBL5045109 | 0.84 | CPT1A (0.45) | EIF4ENOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | AR 662/4885EIF4E 2174/4885PTPRF 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.