SCHEMBL6877689

SCHEMBL6877689

CCOC(=O)C(=O)c1csc(NC(=O)C23CC4CCCC(C2)C(C4)C3)n1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
GAA P10253 1/20 0.41
HTT P42858 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
ALDH1A1 P00352 3/20 0.38
TDP1 Q9NUW8 2/20 0.38
HPGD P15428 2/20 0.37
MAPT P10636 1/20 0.37
NPC1 O15118 4/20 0.37
RAB9A P51151 4/20 0.37
KDM4E B2RXH2 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CNR1 P21554 1/20 0.36
POLB P06746 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1758687 0.87 CNR2 (0.63) CNR2SMN1; SMN2GAAHTTNPSR1
SCHEMBL6879293 0.78 GAA (0.49) CNR2SMN1; SMN2GAAHTTNPSR1
SCHEMBL6879978 0.72 CNR2 (0.45) CNR2SMN1; SMN2GAAHTTALDH1A1
SCHEMBL10465534 0.71 SMN1; SMN2 (0.60) SMN1; SMN2HTTCYP1A2CYP2C19ALDH1A1
SCHEMBL10465715 0.69 CYP1A2 (0.54) SMN1; SMN2GAANPSR1CYP1A2CYP2C19
SCHEMBL14417570 0.69 NR3C1 (0.68) SMN1; SMN2GAACYP1A2CYP2C19ALDH1A1
SCHEMBL16078326 0.69 CYP1A2 (0.55) CNR2SMN1; SMN2GAAHTTCYP1A2
SCHEMBL19481652 0.69 CYP1A2 (0.52) SMN1; SMN2GAAHTTNPSR1CYP1A2
SCHEMBL10549081 0.68 CYP1A2 (0.60) SMN1; SMN2GAACYP1A2CYP2C19ALDH1A1
SCHEMBL14398955 0.68 ALDH1A1 (0.40) NPSR1CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011058582-A1 HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF FUNGAL INFECTIONS ORCHID RESEARCH LABORATORIES LTD. (IN) 2011-05-19 WO disclosed