Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 6/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877450 | 1.00 | MAPK8 (0.40) | MAPK8MAPK9MAPK10DRD2PYGL | |
| SCHEMBL6868816 | 0.87 | CNR1 (0.39) | MAPK8MAPK9MAPK10JAK3MAPK14 | |
| SCHEMBL6879152 | 0.86 | DRD2 (0.42) | MAPK8MAPK9MAPK10DRD2ACHE | |
| SCHEMBL6879155 | 0.86 | DRD2 (0.42) | MAPK8MAPK9MAPK10DRD2ACHE | |
| SCHEMBL6876646 | 0.81 | MAPK8 (0.42) | MAPK8MAPK9MAPK10DRD2ACHE | |
| SCHEMBL6876639 | 0.81 | MAPK8 (0.42) | MAPK8MAPK9MAPK10DRD2ACHE | |
| SCHEMBL6875935 | 0.79 | EHMT2 (0.39) | PYGLACHEALDH1A1LMNAHTT | |
| SCHEMBL6875943 | 0.79 | EHMT2 (0.39) | PYGLACHEALDH1A1LMNAHTT | |
| SCHEMBL6867773 | 0.79 | ALDH1A1 (0.54) | MAPK8MAPK9MAPK10ACHEALDH1A1 | |
| SCHEMBL6878045 | 0.79 | HRH4 (0.42) | MAPK8MAPK9MAPK10DRD2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |