Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 9/20 | 0.42 |
| ▸ | BCHE | P06276 | 7/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466543 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2AACHEBCHECNR1 | |
| SCHEMBL6873997 | 0.90 | ALDH1A1 (0.51) | MCHR1ADRA2AACHEBCHECNR1 | |
| SCHEMBL6462936 | 0.90 | ALDH1A1 (0.51) | MCHR1ADRA2AACHEBCHECNR1 | |
| SCHEMBL6868411 | 0.83 | MCHR1 (0.39) | MCHR1ADRA2AACHEBCHEALDH1A1 | |
| SCHEMBL6868414 | 0.83 | MCHR1 (0.39) | MCHR1ADRA2AACHEBCHEALDH1A1 | |
| SCHEMBL6876352 | 0.83 | MCHR1 (0.50) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6463847 | 0.83 | MCHR1 (0.42) | MCHR1ADRA2AACHEBCHECNR1 | |
| SCHEMBL6879122 | 0.83 | MCHR1 (0.42) | MCHR1ADRA2AACHEBCHECNR1 | |
| SCHEMBL6876346 | 0.83 | MCHR1 (0.50) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6879219 | 0.83 | ALDH1A1 (0.55) | MCHR1ADRA2AACHEBCHETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |