Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.56 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878421 | 1.00 | MCHR1 (0.56) | MCHR1ADRA2ASMYD3HTR1AADRA1A | |
| SCHEMBL6455454 | 0.89 | MCHR1 (0.70) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6455447 | 0.89 | MCHR1 (0.70) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6875778 | 0.89 | MCHR1 (0.47) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6455831 | 0.89 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6455836 | 0.89 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6463580 | 0.88 | LMNA (0.55) | MCHR1ADRA2ASMYD3KDM4EMEN1 | |
| SCHEMBL6463573 | 0.88 | LMNA (0.55) | MCHR1ADRA2ASMYD3KDM4EMEN1 | |
| SCHEMBL6879865 | 0.87 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6879862 | 0.87 | MCHR1 (0.57) | MCHR1ADRA2AHTR1AADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |