Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL686627 | 0.90 | SMN1; SMN2 (0.42) | KMT2ASMN1; SMN2LMNANPSR1ITGB1 | |
| SCHEMBL687205 | 0.89 | FFAR1 (0.38) | KMT2ANPSR1P2RX3MEN1MAPT | |
| SCHEMBL686979 | 0.86 | KMT2A (0.38) | KMT2AMEN1POLB | |
| SCHEMBL687913 | 0.86 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2LMNANPSR1MEN1 | |
| SCHEMBL687724 | 0.81 | SMN1; SMN2 (0.36) | KMT2ASMN1; SMN2NPSR1POLBFFAR1 | |
| SCHEMBL687242 | 0.80 | SMN1; SMN2 (0.44) | KMT2ASMN1; SMN2LMNANPSR1ITGB1 | |
| SCHEMBL686761 | 0.80 | SMN1; SMN2 (0.37) | KMT2ASMN1; SMN2NPSR1MEN1POLB | |
| SCHEMBL687713 | 0.80 | CTSA (0.37) | KMT2ASMN1; SMN2NPSR1ITGB1ITGA4 | |
| SCHEMBL687881 | 0.80 | PTGER3 (0.40) | NPSR1MAPTFFAR1 | |
| SCHEMBL688419 | 0.79 | SMN1; SMN2 (0.35) | KMT2ASMN1; SMN2P2RX3FFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |