Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 7/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687472 | 0.89 | KMT2A (0.41) | KMT2ACTSACYP26A1MEN1KEAP1 | |
| SCHEMBL687127 | 0.88 | PTGER3 (0.42) | CTSACNR2 | |
| SCHEMBL687870 | 0.86 | KMT2A (0.40) | KMT2AMEN1POLB | |
| SCHEMBL687205 | 0.85 | FFAR1 (0.38) | KMT2AMEN1 | |
| SCHEMBL687304 | 0.85 | KEAP1 (0.41) | KMT2ACTSACYP26A1MEN1KEAP1 | |
| SCHEMBL688120 | 0.84 | CTSA (0.42) | CTSAPOLB | |
| SCHEMBL688643 | 0.84 | PTGER3 (0.41) | CTSACNR2 | |
| SCHEMBL687713 | 0.83 | CTSA (0.37) | KMT2ACTSAMEN1POLB | |
| SCHEMBL688399 | 0.83 | PTGER3 (0.40) | CTSACNR2 | |
| SCHEMBL687408 | 0.82 | KMT2A (0.43) | KMT2ACTSACYP26A1MEN1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |