Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879666 | 1.00 | MCHR1 (0.40) | MCHR1TP53ADRA2AHTTGLA | |
| SCHEMBL6463450 | 0.92 | MCHR1 (0.44) | MCHR1TP53ADRA2AHTTKDM4E | |
| SCHEMBL6463465 | 0.92 | MCHR1 (0.44) | MCHR1TP53ADRA2AHTTKDM4E | |
| SCHEMBL6473886 | 0.91 | EPHX1 (0.42) | MCHR1TP53ADRA2AKDM4ELMNA | |
| SCHEMBL6467863 | 0.91 | EPHX1 (0.42) | MCHR1TP53ADRA2AKDM4ELMNA | |
| SCHEMBL6877014 | 0.89 | KDM4E (0.41) | MCHR1ADRA2AHTTGLAKDM4E | |
| SCHEMBL6878770 | 0.89 | ALDH1A1 (0.45) | MCHR1TP53ADRA2AKDM4ELMNA | |
| SCHEMBL6878768 | 0.89 | ALDH1A1 (0.45) | MCHR1TP53ADRA2AKDM4ELMNA | |
| SCHEMBL6877017 | 0.89 | KDM4E (0.41) | MCHR1ADRA2AHTTGLAKDM4E | |
| SCHEMBL6877493 | 0.85 | TP53 (0.49) | MCHR1TP53ADRA2AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |