Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687751 | 0.94 | SMN1; SMN2 (0.40) | RXFP1CTSAPOLBGAAFFAR1 | |
| SCHEMBL687342 | 0.92 | CTSA (0.41) | NPSR1RXFP1CTSAPOLBPTGER3 | |
| SCHEMBL688112 | 0.92 | KMT2A (0.41) | CTSAPOLBKEAP1NFE2L2CYP26A1 | |
| SCHEMBL687773 | 0.87 | CTSA (0.41) | CTSACYP26A1PTGER3 | |
| SCHEMBL687744 | 0.86 | PTGER3 (0.43) | NPSR1RXFP1CTSATP53GAA | |
| SCHEMBL29371834 | 0.85 | PTGER3 (0.44) | CTSAPTGER3 | |
| SCHEMBL686896 | 0.85 | PTGER3 (0.44) | CTSAPTGER3 | |
| SCHEMBL687640 | 0.85 | PTGER3 (0.40) | NPSR1RXFP1TP53GAAPTGER3 | |
| SCHEMBL688125 | 0.85 | CTSA (0.46) | RXFP1CTSAFFAR1CYP26A1 | |
| SCHEMBL688008 | 0.84 | CTSA (0.41) | CTSATP53GAACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |