Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 9/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688232 | 0.91 | CTSA (0.42) | CTSACYP26A1 | |
| SCHEMBL29371834 | 0.90 | PTGER3 (0.44) | CTSA | |
| SCHEMBL686896 | 0.90 | PTGER3 (0.44) | CTSA | |
| SCHEMBL687472 | 0.89 | KMT2A (0.41) | CTSAMEN1KMT2ACYP26A1ALDH1A1 | |
| SCHEMBL686868 | 0.88 | CTSA (0.42) | CTSAMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL687628 | 0.87 | KMT2A (0.42) | CTSAMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL687773 | 0.87 | CTSA (0.41) | CTSACYP26A1 | |
| SCHEMBL687304 | 0.86 | KEAP1 (0.41) | CTSAMEN1KMT2ACYP26A1ALDH1A1 | |
| SCHEMBL688301 | 0.86 | PTGER4 (0.42) | CTSAALDH1A1 | |
| SCHEMBL687342 | 0.85 | CTSA (0.41) | CTSAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |