Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688202 | 0.93 | KDM4E (0.41) | MAPTALDH1A1KDM4ESMN1; SMN2PTGER3 | |
| SCHEMBL688082 | 0.90 | TP53 (0.41) | MAPTALDH1A1KDM4ESMN1; SMN2CTSA | |
| SCHEMBL688357 | 0.90 | POLB (0.41) | MAPTALDH1A1KDM4EPTGER3CTSA | |
| SCHEMBL687369 | 0.88 | WDR5 (0.44) | MAPTALDH1A1KDM4EPTGER3PTGER4 | |
| SCHEMBL688110 | 0.88 | MEN1 (0.49) | MAPTALDH1A1KDM4ECTSATP53 | |
| SCHEMBL687932 | 0.87 | EGLN1 (0.44) | MAPTALDH1A1KDM4ESMN1; SMN2PTGER3 | |
| SCHEMBL687511 | 0.86 | MEN1 (0.46) | MAPTALDH1A1KDM4ESMN1; SMN2CTSA | |
| SCHEMBL688277 | 0.86 | MEN1 (0.39) | ALDH1A1KDM4ESMN1; SMN2CTSAATM | |
| SCHEMBL686843 | 0.86 | MAPT (0.47) | MAPTALDH1A1KDM4ESMN1; SMN2PTGER3 | |
| SCHEMBL688248 | 0.86 | POLB (0.39) | MAPTALDH1A1KDM4ECTSALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |