Dipyridyl

Dipyridyl

SCHEMBL687954

O=C1CCC(=O)N1O.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.54
LMNA P02545 3/20 0.54
CCR1 P32246 3/20 0.54
CCR5 P51681 3/20 0.54
CCR8 P51685 3/20 0.54
P4HTM Q9NXG6 2/20 0.54
CYP1A2 P05177 1/20 0.54
POLB P06746 1/20 0.54
METAP1 P53582 1/20 0.54
BLM P54132 1/20 0.54
HIF1A Q16665 1/20 0.54
DOHH Q9BU89 1/20 0.54
TP53 P04637 4/20 0.47
ALOX15 P16050 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
NPC1 O15118 3/20 0.47
HTT P42858 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
RAB9A P51151 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dipyridyl SCHEMBL18920847 1.00 KDM4E (0.54) KDM4ELMNACCR1CCR5CCR8
Dipyridyl SCHEMBL8655290 0.98 KDM4E (0.52) KDM4ELMNACCR1CCR5CCR8
Dipyridyl SCHEMBL18917065 0.98 KDM4E (0.52) KDM4ELMNACCR1CCR5CCR8
Dipyridyl SCHEMBL8655285 0.98 KDM4E (0.52) KDM4ELMNACCR1CCR5CCR8
Dipyridyl SCHEMBL28137298 0.81 KDM4E (0.54) KDM4ELMNACCR1CCR5CCR8
SCHEMBL18191184 0.80 EHMT2 (0.59) LMNAPOLBSMN1; SMN2NPC1L3MBTL1
2-Picolinic Acid SCHEMBL994022 0.79 L3MBTL1 (0.67) KDM4ELMNAP4HTMSMN1; SMN2NPC1
SCHEMBL18191183 0.78 EHMT2 (0.41) LMNAPOLBSMN1; SMN2NPC1L3MBTL1
Dipyridyl SCHEMBL27651116 0.73 KDM4E (0.88) KDM4ELMNACCR1CCR5CCR8
Dipyridyl SCHEMBL29907716 0.73 KDM4E (1.00) KDM4ELMNACCR1CCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3384288-B1 METHOD FOR REDUCTION OF INTERFERENCES IN IMMUNOASSAYS ROCHE DIAGNOSTICS GMBH (DE) 2024-01-10 EP disclosed
US-20180086835-A1 LIGANDS THAT BIND TGF-BETA RECEPTOR II GLAXO GROUP LIMITED (GB) 2018-03-29 US disclosed
US-9850307-B2 Nucleic acids encoding immunoglobulins that bind TGF-beta receptor II GLAXO GROUP LIMITED (GB) 2017-12-26 US disclosed
EP-2661449-B1 LIGANDS THAT BIND TGF-BETA RECEPTOR II GLAXO GROUP LTD (GB) 2017-03-22 EP disclosed
US-20150361176-A1 LIGANDS THAT BIND TGF-BETA RECEPTOR II GLAXO GROUP LIMITED 2015-12-17 US disclosed
US-9150651-B2 Single variable domain immunoglobulins that bind TGF-beta receptor II GLAXO GROUP LIMITED (GB) 2015-10-06 US disclosed
US-20130302335-A1 LIGANDS THAT BIND TGF-BETA RECEPTOR II GLAXO GROUP LIMITED (GB) 2013-11-14 US disclosed
EP-2661449-A1 LIGANDS THAT BIND TGF-BETA RECEPTOR II Glaxo Group Limited (GB) 2013-11-13 EP disclosed
WO-2012093125-A1 LIGANDS THAT BIND TGF-BETA RECEPTOR II GLAXO GROUP LIMITED (GB) 2012-07-12 WO disclosed
EP-2009444-B1 NON-INVASIVE TEST METHOD FOR NON-ALCOHOLIC STEATOHEPATITIS BASED ON CYTOCHROME-C QUANTIFICATION EISAI R&D MAN CO LTD (JP) 2012-02-29 EP disclosed
EP-1873523-B1 IMMUNOCHEMICAL DETERMINATION METHOD FOR CYTOCHROME C EISAI R&D MAN CO LTD (JP) 2011-11-30 EP disclosed
US-7892757-B2 Immunochemical determination method and determination reagent for cytochrome c EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-02-22 US disclosed
US-20090111122-A1 METHOD FOR NON-INVASIVE EXAMINATION OF NON-ALCOHOLIC STEATOHEPATITIS BY QUANTIFICATION OF CYTOCHROME-c, AND TEST KIT EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-04-30 US disclosed
US-20090075290-A1 IMMUNOCHEMICAL DETERMINATION METHOD AND DETERMINATION REAGENT FOR CYTOCHROME EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-03-19 US disclosed
EP-2009444-A1 METHOD FOR NON-INVASIVE EXAMINATION OF NON-ALCOHOLIC STEATOHEPATITIS BY QUANTIFICATION OF CYTOCHROME-c, AND TEST KIT Eisai R&D Management Co., Ltd. (JP) 2008-12-31 EP disclosed
EP-1873523-A1 IMMUNOCHEMICAL DETERMINATION METHOD AND DETERMINATION REAGENT FOR CYTOCHROME C Eisai R&D Management Co., Ltd. (JP) 2008-01-02 EP disclosed