Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879594 | 1.00 | NPC1 (0.57) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6875057 | 0.94 | NPC1 (0.48) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6875046 | 0.94 | NPC1 (0.48) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6876788 | 0.92 | NPC1 (0.47) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6876802 | 0.92 | NPC1 (0.47) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6880607 | 0.91 | PKM (0.55) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6880600 | 0.91 | PKM (0.55) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6867093 | 0.90 | MEN1 (0.45) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6867086 | 0.90 | MEN1 (0.45) | NPC1LMNAMCHR1ADRA2AADRA1A | |
| SCHEMBL6868594 | 0.89 | MAPT (0.47) | NPC1LMNAMCHR1ADRA2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |