Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880607 | 1.00 | PKM (0.55) | PKMALOX15CXCR3MCHR1ADRA2A | |
| SCHEMBL6867915 | 0.92 | EPHX2 (0.49) | PKMALOX15CXCR3MCHR1ADRA2A | |
| SCHEMBL6867921 | 0.92 | EPHX2 (0.49) | PKMALOX15CXCR3MCHR1ADRA2A | |
| SCHEMBL6879588 | 0.91 | NPC1 (0.57) | PKMALOX15MCHR1ADRA2AADRA1A | |
| SCHEMBL6879594 | 0.91 | NPC1 (0.57) | PKMALOX15MCHR1ADRA2AADRA1A | |
| SCHEMBL7109737 | 0.90 | NPC1 (0.54) | PKMALOX15MCHR1ADRA2AADRA1A | |
| SCHEMBL7109740 | 0.90 | NPC1 (0.54) | PKMALOX15MCHR1ADRA2AADRA1A | |
| SCHEMBL6873819 | 0.90 | EPHX1 (0.53) | PKMALOX15MCHR1ADRA2AADRA1A | |
| SCHEMBL6873818 | 0.90 | EPHX1 (0.53) | PKMALOX15MCHR1ADRA2AADRA1A | |
| SCHEMBL6876244 | 0.89 | NPC1 (0.53) | PKMALOX15CXCR3MCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |