Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 8/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155720 | 1.00 | KDM4E (0.44) | KDM4EGAAMAPTL3MBTL1LMNA | |
| SCHEMBL9449579 | 0.81 | KDM4E (0.53) | KDM4EGAAMAPTL3MBTL1LMNA | |
| SCHEMBL9449576 | 0.81 | KDM4E (0.53) | KDM4EGAAMAPTL3MBTL1LMNA | |
| SCHEMBL6158301 | 0.78 | NPC1 (0.42) | GAAMAPTL3MBTL1LMNAMAPK1 | |
| SCHEMBL6881407 | 0.78 | NPC1 (0.42) | GAAMAPTL3MBTL1LMNAMAPK1 | |
| SCHEMBL16683714 | 0.75 | KDM4E (0.53) | KDM4EGAAMAPTL3MBTL1LMNA | |
| SCHEMBL13128199 | 0.75 | KDM4E (0.53) | KDM4EGAAMAPTL3MBTL1LMNA | |
| SCHEMBL10101738 | 0.75 | L3MBTL1 (0.51) | KDM4EGAAMAPTL3MBTL1LMNA | |
| SCHEMBL6878835 | 0.74 | NR4A2 (0.44) | L3MBTL1NPC1RAB9APPARGPPARA | |
| SCHEMBL6878832 | 0.74 | VDR (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |