Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869609 | 0.80 | KDM4E (0.55) | ALDH1A1KDM4ECYP1A2HTTNPC1 | |
| SCHEMBL6852407 | 0.80 | PIK3CD (0.33) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL6853750 | 0.79 | MAPK14 (0.39) | MELKMAPK14DPP4ALDH1A1CYP2D6 | |
| SCHEMBL6879818 | 0.79 | CYP2A6 (0.56) | MAPK14CYP2A6ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL6847889 | 0.76 | MAPK14 (0.51) | MELKMAPK14DPP4CYP2A6CDC7 | |
| SCHEMBL6854322 | 0.76 | HDAC1 (0.41) | MELKMAPK14DPP4ALDH1A1KDM4E | |
| SCHEMBL6852026 | 0.76 | KDM4E (0.33) | CYP2A6PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL6854759 | 0.75 | MAPK14 (0.38) | MELKMAPK14DPP4CYP2A6ALDH1A1 | |
| SCHEMBL6852362 | 0.72 | CYP2C9 (0.49) | MELKCYP2A6PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6847882 | 0.71 | MELK (0.35) | MELKMAPK14PIEZO1CYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |