Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.51 |
| ▸ | PRKCI | P41743 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879818 | 0.83 | CYP2A6 (0.56) | MAPK14HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6854759 | 0.82 | MAPK14 (0.38) | MAPK14MELKCYP2A6DPP4CYP1A2 | |
| SCHEMBL6853750 | 0.80 | MAPK14 (0.39) | MAPK14MELKDPP4CYP2D6MAPT | |
| SCHEMBL6854070 | 0.77 | HDAC3 (0.41) | PRKCIHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6854322 | 0.77 | HDAC1 (0.41) | MAPK14HDAC1MELKDPP4MAPT | |
| SCHEMBL6847879 | 0.76 | MELK (0.37) | MAPK14MELKCYP2A6DPP4CYP1A2 | |
| SCHEMBL6869609 | 0.74 | KDM4E (0.55) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6854124 | 0.73 | HDAC3 (0.41) | PRKCIHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6852047 | 0.73 | MAPK14 (0.51) | MAPK14PRKCIMELKCYP2A6CYP1A2 | |
| SCHEMBL8013270 | 0.73 | DPP4 (0.51) | MAPK14HDAC1DPP4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |