Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | FABP4 | P15090 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3755432 | 0.77 | HTR6 (0.58) | HTR6 | |
| SCHEMBL6391784 | 0.57 | MEN1 (0.60) | MEN1KMT2AALDH1A1 | |
| SCHEMBL10698414 | 0.56 | CYP2C19 (0.51) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9324870 | 0.55 | MEN1 (0.57) | MEN1KMT2AALDH1A1 | |
| SCHEMBL13450967 | 0.55 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1TP53THRB | |
| Trifluoroacetic Acid SCHEMBL27585620 | 0.55 | ALDH1A1 (0.65) | HTR5AKMT2AALDH1A1 | |
| SCHEMBL3744515 | 0.55 | HTR6 (0.74) | HTR6ALDH1A1 | |
| SCHEMBL8120827 | 0.54 | ALDH1A1 (0.52) | KMT2AFABP4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL525413 | 0.54 | LIMK2 (0.65) | HTR5AMEN1KMT2AALDH1A1 | |
| SCHEMBL14002159 | 0.54 | KMT2A (0.55) | HTR6HTR5AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476151-A1 | 1-ARYLSULFONYL-3-SUBSTITUED INDOLE AND INDOLINE DERIVATES USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Akzo Nobel N.V. (NL) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068220-A1 | 1-ARYLSULFONYL-3-SUBSTITUTED INDOLE AND INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | AKZO NOBEL N.V. (NL) | 2003-08-21 | — | — | WO | disclosed |