Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2416319 | 0.81 | ALDH1A1 (0.53) | DYRK1ADYRK1BDYRK2CHRM2CHRM1 | |
| SCHEMBL14103572 | 0.81 | DYRK1A (0.41) | DYRK1ADYRK1BDYRK2CHRM2CHRM1 | |
| SCHEMBL28902687 | 0.81 | CHRM2 (0.43) | DYRK1ADYRK1BDYRK2CHRM2CHRM1 | |
| SCHEMBL18255131 | 0.75 | XDH (0.43) | DYRK1ADYRK1BDYRK2CHRM2CHRM1 | |
| SCHEMBL26622867 | 0.75 | OGA (0.52) | — | |
| SCHEMBL26622853 | 0.75 | OGA (0.52) | — | |
| SCHEMBL267355 | 0.74 | LMNA (0.53) | DYRK1ACHRM2CHRM1CHRNB2CHRM3 | |
| SCHEMBL15673283 | 0.73 | KDM4E (0.69) | KDM4EMMP1 | |
| SCHEMBL15673282 | 0.73 | KDM4E (0.69) | KDM4EMMP1 | |
| SCHEMBL19141318 | 0.71 | CHRM2 (0.41) | DYRK1ADYRK1BDYRK2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084991-A2 | FLUORINATED HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-14 | — | — | WO | disclosed |